Influence of the Polymer and Solvent Variables on the Nanoencapsulation of the Flavonoid Quercetin: Preliminary Study Based on Eudragit® Polymers

Eudragit® polymers have proven their potential as a means to control the release of aqueous insoluble drugs in various delivery systems polymer nanoparticles (PNPs). The size (S) and polydispersity index (PDI) PNPs are crucial factors for interaction with biological from pharmaceutical standpoint. This study aimed determine impact volumes organic phase (OP) (AP), well amount (PA), on PDI prepared using nanoprecipitation method encapsulating quercetin (Qr). also evaluated toxic effects human erythrocytes. were preformed derived methacrylic acid polyvinyl alcohol (PVA) surfactant. technique enabled production particles smaller than 200 nm lower 0.2, established significant (p < 0.05) three variables related solvents. selected contained 5 mg Qr 50 Eudragit (1:10 w/w EPO, E100, L100, L100-55) diverse concentrations PVA. found that including PVA AP increased encapsulation by up 98%. hemolytic was assessed erythrocytes, no cytotoxic activity observed 0.001) compared control. In conclusion, via technique, preparing defined homogeneous S entrap flavonol efficiently is possible.